研究方向說明(Research abstract)

Cancers arise with multiple mechanisms, leading to the difficulty for anticancer therapy. To understand how cancers develop, we firstly focused our study on identifying novel genes with altered expression in cancer tissues. Several genes upregulated or downregulated in lung cancer tissues have been identified and the mechanisms by which they induced cancer formation are partly resolved. Intriguingly, we found that many of those cancer related genes are functionally linked to organelle. For example, the potential oncoprotein HURP regulates the expression of many Golgi assembly factors. Additionally, when HURP is phosphorylated by the oncogenic kinase Aurora-A, the pHURP assembles Golgi ribbon by attracting and stabilizing some cis-Golgi assembly factors, and positions Golgi complex by interacting with nuclear membrane protein Synes.

 

Golgi complex has been pointed out participating in cancer development recently. Firstly, abnormal fragmentation of Golgi complex releases and activates certain oncogenic factors. Secondly, Golgi complex repositions to the cell leading end during cell migration, directionaly provding essential factors for cell movement. We found that HURP, after being methylated by the methyltransferase PRMT5, impaired cell migration via rigidifying Golgi complex; on the contrary, the unmethylated HURP stimulated cell migration by promoting Golgi repositioning via Cdc42-dependent pathway. Thirdly, Golgi complex is fragmented during aggresome formation. Aggresome is a relatively new organelle engaged in quarantining and clearing the misfolded proteins when proteasome fails to remove those protein garbage. We found that aggresome is only generated when Golgi complex is disassembled, thereby releasing some essential factors to the former. Some of those factors enter and enlarge centrosome, and finally aggresome is constructed on the enlarged centrosome. Hence, we are working on how Golgi complex, centrosome and aggresome coordinate each other to ensure the construction of aggresome during protein misfolding pressure, which is highly toxic to cells. Tremendous amounts of misfolded proteins are found in cancer cells, where aggresome is built up to clear those toxic proteins. Inactivation of aggresome is reported providing a alternative way to kill cancer cells. We are on the process testing the cancer cell killing effect of various inhibitors for the aggresome constructing factors released from Golgi complex.

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​期刊論文(Journal papers)

42. Chiu SC, Yang XT, Wei TW, Liao YA, Chen JM, Kuo YC, Liu CJ, Cheng CY, Huang YJ, Huang YJ, Wu HJ, Wan CX, Tsai JR, Yu CR*. The crescent-like Golgi ribbon is shaped by the Ajuba/PRMT5/Aurora-A complex-modified HURP. Cell Commun Signal. 2023 Jun 27;21(1):156. doi: 10.1186/s12964-023-01167-4. PMID: 37370099; PMCID: PMC10294536.

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41. Huang YJ, Chiu SC, Tseng JS, Chen JM, Wei TW, Chu CY, Kao HE, Yang CO, Shih YE, Yang TY, Chiu KY, Teng CJ, Yu CR*. The JMJD6/HURP axis promotes cell migration via NF-κB-dependent centrosome repositioning and Cdc42-mediated Golgi repositioning. J Cell Physiol. 2022 Dec;237(12):4517-4530. doi: 10.1002/jcp.30900. Epub 2022 Oct 17. PMID: 36250981.

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40. Chiu SC, Huang YJ, Wei TW, Chen JM, Kuo YC, Huang YJ, Liao YA, Yu CR*. The PRMT5/HURP axis retards Golgi repositioning by stabilizing acetyl-tubulin and Golgi apparatus during cell migration. J Cell Physiol. 2022 Jan;237(1):1033-1043. doi: 10.1002/jcp.30589. Epub 2021 Sep 19. PMID: 34541678.

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39. Yang LY, Tsai MY, Juan SH, Chang SF, Yu CR, Lin JC, Johnson KR, Lim HG, Fann YC, Lee YG. Exerting the Appropriate Application of Methylprednisolone in Acute Spinal Cord Injury Based on Time Course Transcriptomics Analysis. Int J Mol Sci. 2021 Dec 1;22(23):13024. doi: 10.3390/ijms222313024. PMID: 34884829; PMCID: PMC8657964.

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38. Lu WL, Yu CR, Lien HM, Sheu GT, Cherng SH. Cytotoxicity of naringenin induces Bax-mediated mitochondrial apoptosis in human lung adenocarcinoma A549 cells. Environ Toxicol. 2020 Dec;35(12):1386-1394. doi: 10.1002/tox.23003. Epub 2020 Jul 15. PMID: 32667124; PMCID: PMC7689782.

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37. Chen JM, Chiu SC, Chen KC, Huang YJ, Liao YA, Yu CR*. Enolase 1 differentially contributes to cell transformation in lung cancer but not in esophageal cancer. Oncol Lett. 2020 Apr;19(4):3189-3196. doi: 10.3892/ol.2020.11427. Epub 2020 Mar 3. PMID: 32256815; PMCID: PMC7074250.

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36. Chen JM, Chen KC, Chiu SC, Chen RY, Hsia JY, Huang YJ, Yu CR*. Differential contribution of protein phosphatase 1α to cell transformation of different cell types. Oncol Rep. 2019 Oct;42(4):1598-1608. doi: 10.3892/or.2019.7272. Epub 2019 Aug 8. PMID: 31524273.

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35. Chiu SC, Chen KC, Hsia JY, Chuang CY, Wan CX, Wei TW, Huang YJ, Chen JM, Liao YA, Yu CR*. Overexpression of Aurora-A bypasses cytokinesis through phosphorylation of suppressed in lung cancer. Am J Physiol Cell Physiol. 2019 Sep 1;317(3):C600-C612. doi: 10.1152/ajpcell.00032.2019. Epub 2019 Jul 17. PMID: 31314582.

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34. Chang CH, Chen MC, Chiu TH, Li YH, Yu WC, Liao WL, Oner M, Yu CR, Wu CC, Yang TY, Teng CJ, Chiu KY, Chen KC, Wang HY, Yue CH, Lai CH, Hsieh JT, Lin H. Arecoline Promotes Migration of A549 Lung Cancer Cells through Activating the EGFR/Src/FAK Pathway. Toxins (Basel). 2019 Mar 28;11(4):185. doi: 10.3390/toxins11040185. PMID: 30925742; PMCID: PMC6521018.

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33. Yu‑Sheng Tsai, Yan Yu Chen, Chun Yu Xu, Yu Cheng Chang, Yang Yang Tsai, Lin Sin Lu, Yueh Chi Lee, Chia Feng Lin, YewChung Sermon Wu. Yung‑Sen Lin, Hsiang Chen, Chang Tze Ricky Yu. Influence of reduced graphene oxide on material, antibacterial, and piezoelectric behaviors of ZnO nanorods on foldable indium tin oxide substrates. Journal of Materials Science: Materials in Electronics. 13 June 2019.

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32. H. CHEN*, W. C. WENG, Y. C. CHANG, J. L. CHIU, C. Y. LI, W. M. SU, Y. T. CHEN, C. C. LU, Y. T. A. LIAO, C. T. R. YU, Y. S. LIN. TUNING ZINC OXIDE NANORODS ON SiO2SUBSTRATES BY INCORPORATING GRAPHENE. Digest Journal of Nanomaterials and Biostructures. 2018 Apr-June. 13(2): p375-380.

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31. Fu-Jye Sheu , Chun-Pei Cho * , Yu-Ting Liao and Chang-Tze Yu. Ag3PO4-TiO2-Graphene Oxide Ternary Composites with Efficient Photodegradation, Hydrogen Evolution, and Antibacterial Properties. Catalysts 2018, 8(2), 57; doi:10.3390/catal8020057 (registering DOI).

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30. Wei TW, Wu PY, Wu TJ, Hou HA, Chou WC, Teng CJ, Lin CR, Chen JM, Lin TY, Su HC, Huang CF, Yu CR, Hsu SL, Tien HF, Tsai MD. Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA. Cancer Res. 2017 Jan 15;77(2):494-508. doi: 10.1158/0008-5472.CAN-16-1004. Epub 2016 Nov 10. PMID: 28069801.

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29. Wei TW, Wu PY, Wu TJ, Hou HA, Chou WC, Teng CJ, Lin CR, Chen JM, Lin TY, Su HC, Huang CF, Yu CR, Hsu SL, Tien HF, Tsai MD. Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA. Cancer Res. 2017 Jan 15;77(2):494-508. doi: 10.1158/0008-5472.CAN-16-1004. Epub 2016 Nov 10. PMID: 28069801.

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28. Chia-Yun Chen*, Li-Jen Hsu, Po-Hsuan Hsiao, Chang-Tze Ricky Yu. SERS detection and antibacterial activity from uniform incorporation of Ag nanoparticles with aligned Si nanowires. Applied Surface Science (2015), Volume 355, 15 November 2015, Pages 197–202

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27. Chen JM, Chiu SC, Wei TY, Lin SY, Chong CM, Wu CC, Huang JY, Yang ST, Ku CF, Hsia JY, Yu CT*. The involvement of nuclear factor-κappaB in the nuclear targeting and cyclin E1 upregulating activities of hepatoma upregulated protein. Cell Signal. 2015 Jan;27(1):26-36. doi: 10.1016/j.cellsig.2014.09.020. Epub 2014 Oct 5. PMID: 25289861.

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26. Wei TY, Hsia JY, Chiu SC, Su LJ, Juan CC, Lee YC, Chen JM, Chou HY, Huang JY, Huang HM, Yu CT*. Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis. Cell Signal. 2014 Dec;26(12):2940-50. doi: 10.1016/j.cellsig.2014.09.014. Epub 2014 Sep 30. PMID: 25277535.

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25. Chiu SC, Chen JM, Wei TY, Cheng TS, Wang YH, Ku CF, Lian CH, Liu CC, Kuo YC, Yu CT*. The mitosis-regulating and protein-protein interaction activities of astrin are controlled by aurora-A-induced phosphorylation. Am J Physiol Cell Physiol. 2014 Sep 1;307(5):C466-78. doi: 10.1152/ajpcell.00164.2014. Epub 2014 Jul 9. PMID: 25009111.

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24. Hsiang Chen, Chin-Pang Chen, Chang-Tze Ricky Yu, Yun Ti Chen, Chin-Chou Teng, Kuang-Yu Lo, Chun Han Lin, Bo-Yun Huanga. Distinct  spatial  profiles  and  antibacterial  effects  of  20-nm  Ag nanoparticles  dripped  on  ZnO  nanorods  grown  on  a polished  Ti  substrate. Applied Surface Science 2014 311:422–425.

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23. Teng CL, Yu CT, Hwang WL, Tsai JR, Liu HC, Hwang GY, Hsu SL. Effector mechanisms of sunitinib-induced G1 cell cycle arrest, differentiation, and apoptosis in human acute myeloid leukaemia HL60 and KG-1 cells. Ann Hematol. 2013 Mar;92(3):301-13. doi: 10.1007/s00277-012-1627-7. Epub 2012 Nov 20. PMID: 23180436.

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22. Wu CC, Yang TY, Yu CT, Phan L, Ivan C, Sood AK, Hsu SL, Lee MH. p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation. Cell Cycle. 2012 Sep 15;11(18):3433-42. doi: 10.4161/cc.21732. Epub 2012 Aug 16. PMID: 22894933; PMCID: PMC3466554.

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21. Wei TY, Juan CC, Hisa JY, Su LJ, Lee YC, Chou HY, Chen JM, Wu YC, Chiu SC, Hsu CP, Liu KL, Yu CT*. Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade. Cancer Sci. 2012 Sep;103(9):1640-50. doi: 10.1111/j.1349-7006.2012.02367.x. Epub 2012 Aug 8. PMID: 22726390; PMCID: PMC7659304.

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20. Yu CT, Hsia JY, Hseih YC, Su LJ, Lee TC, Ku CF, Chen KS, Chen JM, Wei TY, Lee YC, Huang CY, Wu YC, Yang CY, Hsu SL. The novel protein suppressed in lung cancer down-regulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A. J Thorac Oncol. 2011 Jun;6(6):988-97. doi: 10.1097/JTO.0b013e318212692e. PMID: 21566536.

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19. Wu CC, Yu CT, Chang GC, Lai JM, Hsu SL. Aurora-A promotes gefitinib resistance via a NF-κB signaling pathway in p53 knockdown lung cancer cells. Biochem Biophys Res Commun. 2011 Feb 11;405(2):168-72. doi: 10.1016/j.bbrc.2011.01.001. Epub 2011 Jan 7. PMID: 21216229.

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18. Chia-Man Chou, Tong-You Wade Wei, Jou-May Maureen Chen, Wei-Ting Chang, Chang-Tze Ricky Yu, and Vincent K. S. Hsiao. Preparation of Nanoporous Polymer Films for Real-Time Viability Monitoring of Cells. Journal of Nanomaterials. 2011; Article ID 436528, 6 pages.

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17. Chang GC, Yu CT, Tsai CH, Tsai JR, Chen JC, Wu CC, Wu WJ, Hsu SL. An epidermal growth factor inhibitor, Gefitinib, induces apoptosis through a p53-dependent upregulation of pro-apoptotic molecules and downregulation of anti-apoptotic molecules in human lung adenocarcinoma A549 cells. Eur J Pharmacol. 2008 Dec 14;600(1-3):37-44. doi: 10.1016/j.ejphar.2008.10.024. Epub 2008 Oct 21. PMID: 18973751.

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16. Lee YC, Yu CT, Lin KP, Chang MH, Hsu SL, Liu YF, Lu YC, Soong BW. MPZ mutation G123S characterization: evidence for a complex pathogenesis in CMT disease. Neurology. 2008 Jan 22;70(4):273-7. doi: 10.1212/01.wnl.0000296828.66915.bf. PMID: 18209201.

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15. Yu CT, Li JH, Lee TC, Lin LF. Characterization of cocaine-elicited cell vacuolation: the involvement of calcium/calmodulin in organelle deregulation. J Biomed Sci. 2008 Mar;15(2):215-26. doi: 10.1007/s11373-007-9213-z. Epub 2007 Oct 7. PMID: 17922255.

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14. Cheng TS, Hsiao YL, Lin CC, Yu CT, Hsu CM, Chang MS, Lee CI, Huang CY, Howng SL, Hong YR. Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin. J Biol Chem. 2008 Jan 25;283(4):2454-64. doi: 10.1074/jbc.M706794200. Epub 2007 Nov 30. PMID: 18055457.

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13. Yu CT, Wu JC, Liao MC, Hsu SL, Huang CY. Identification of c-Fos as a mitotic phosphoprotein: regulation of c-Fos by Aurora-A. J Biomed Sci. 2008 Jan;15(1):79-87. doi: 10.1007/s11373-007-9209-8. Epub 2007 Oct 10. PMID: 17926144.

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12. Cheng TS, Hsiao YL, Lin CC, Hsu CM, Chang MS, Lee CI, Yu RC, Huang CY, Howng SL, Hong YR. hNinein is required for targeting spindle-associated protein Astrin to the centrosome during the S and G2 phases. Exp Cell Res. 2007 May 1;313(8):1710-21. doi: 10.1016/j.yexcr.2007.02.023. Epub 2007 Mar 7. PMID: 17383637.

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11. Cherng SH, Hsu SL, Yang JL, Yu CT, Lee H. Suppressive effect of 1-nitropyrene on benzo[a]pyrene-induced CYP1A1 protein expression in HepG2 cells. Toxicol Lett. 2006 Mar 1;161(3):236-43. doi: 10.1016/j.toxlet.2005.10.002. Epub 2005 Nov 8. PMID: 16280210.

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10. Lin YS, Su LJ, Yu CT, Wong FH, Yeh HH, Chen SL, Wu JC, Lin WJ, Shiue YL, Liu HS, Hsu SL, Lai JM, Huang CY. Gene expression profiles of the aurora family kinases. Gene Expr. 2006;13(1):15-26. doi: 10.3727/000000006783991962. PMID: 16572587; PMCID: PMC6032448.

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9. Hsu SL, Yu CT, Yin SC, Tang MJ, Tien AC, Wu YM, Huang CY. Caspase 3, periodically expressed and activated at G2/M transition, is required for nocodazole-induced mitotic checkpoint. Apoptosis. 2006 May;11(5):765-71. doi: 10.1007/s10495-006-5880-x. PMID: 16532268.

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8. Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol Cell Biol. 2005 Jul;25(14):5789-800. doi: 10.1128/MCB.25.14.5789-5800.2005. PMID: 15987997; PMCID: PMC1168800.

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7. Wu JC, Chen TY, Yu CT, Tsai SJ, Hsu JM, Tang MJ, Chou CK, Lin WJ, Yuan CJ, Huang CY. Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J Biol Chem. 2005 Mar 11;280(10):9013-22. doi: 10.1074/jbc.M411068200. Epub 2005 Jan 5. PMID: 15637052.

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6. Yan-Nian Chen, Chi-Chih Cheng, Chang-Tze R. Yu, Su-Jen Chou, Hong-Chen Chen, and Shih-Lan Hsu*. Involvement of intrinsic and extrinsic apoptotic pathways in Baicalein-induced apoptosis in human hepatoma Hep3B cells. Journal of Cancer Molecules. 2005; 1: 37-45.

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5. Hsu JM, Lee YC, Yu CT, Huang CY. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. J Biol Chem. 2004 Jul 30;279(31):32592-602. doi: 10.1074/jbc.M404950200. Epub 2004 May 15. PMID: 15145941.

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4. Tsou AP, Yang CW, Huang CY, Yu RC, Lee YC, Chang CW, Chen BR, Chung YF, Fann MJ, Chi CW, Chiu JH, Chou CK. Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene. 2003 Jan 16;22(2):298-307. doi: 10.1038/sj.onc.1206129. PMID: 12527899.

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3. Yu RC, Lee TC, Wang TC, Li JH. Genetic toxicity of cocaine. Carcinogenesis. 1999 Jul;20(7):1193-9. doi: 10.1093/carcin/20.7.1193. PMID: 10383889.

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2. Sun YH, Tsai CJ, Green MM, Chao JL, Yu CT, Jaw TJ, Yeh JY, Bolshakov VN. White as a reporter gene to detect transcriptional silencers specifying position-specific gene expression during Drosophila melanogaster eye development. Genetics. 1995 Nov;141(3):1075-86. doi: 10.1093/genetics/141.3.1075. PMID: 8582614; PMCID: PMC1206831.

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1. You CT, Sun YH. Tilted agarose gel electrophoresis improves resolution. Biotechniques. 1995 Oct;19(4):574-5. PMID: 8777047.

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執行計畫(Research grants)

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28. 解析JMJD6-HURP-NF-кB透過組建新月型Golgi ribbon來刺激細胞移行的機制（續提計畫）(Exploring the mechanisms by which the JMJD6-HURP-NF-B axispromotes cell migration via assembling crescent-like Golgi ribbon (continued))，112-2320-B-260-001-，2023/8/1~2024/7/30 (國科會計畫)（主持人）。

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27. 共處理Regorafenib與蛋白酶體抑制劑引發細胞死亡的機制與應用（The underlined mechanisms and application for  Regorafenib/proteasome inhibitor-induced cytotoxicity in the lung cancer A549 cells），TCVGH-NCNU1127903，2022/01/01~2022/12/31 (榮暨計畫)（主持人）。

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26. 解析JMJD6-HURP-NF-B透過組建Golgi ribbon來刺激細胞移行的機制 (Exploring the mechanisms by which The JMJD6-HURP-NF-kB axis promotes cell mihration via assembling Golgi ribbon), MOST 111-2320-B-260-001-，2022/8/1~2023/7/30 (科技部計畫)（主持人）。

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25. 高基氏體與修飾微管在aggresome形成時的角色分析(The role of Golgi complex and modified tubulins in the formation of aggresome), TCVGH-NCNU1107903，2021/01/01~2021/12/31 (榮暨計畫)（主持人）。

 

24. 尋找抑制aggresome形成與加強MG132細胞毒性的抗癌藥物 (Screen for the conventional anticancer drugs able to block aggresome formation and enhance MG132-induced cell toxicity)，TCVGH-NCNU1097903，2020/01/01~2020/12/31 (榮暨計畫)（主持人）。

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23. 探討Ajuba/PRMT5/Aurora-A複合體透過修飾HURP與HDAC6調節aggresome結構功能的機制與其毒殺癌細胞的應用潛力(The effects of Ajuba-PRMT5-Aurora-A complex mediated modification of HURP and HDAC6 on the regulation of aggresome formation and its potential application on cancer cell killing)，MOST 108-2320-B-260-001，2019/8/1~2020/7/31 (科技部計畫)（主持人）。

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22. 分析HURP刺激細胞移行的機制 (Exploring the mechanisms by which HURP stimulates cell migration) ，TCVGH-NCNU1087901，2019/01/01~2019/12/31 (榮暨計畫)（主持人）。

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21. 分析具致癌潛力的PRMT5與Aurora-A共同修飾產生Golgi調控因子HURP p725的機制 (Exploring the mechanisms by which the oncogenic PRMT5 and Aurora-A work together to produce the Golgi assembly factor HURP p725)，TCVGH-NCNU1077902，2018/01/01~2018/12/31 (榮暨計畫)（主持人）。

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20. 分析HURP p725與vimentin intermediate filament的相互調控 (The analysis for the interplay of HURP p725 and vimentin intermediate filament)，TCVGH-NCNU1067902，執行期限：2017/01/01~2017/12/31 (榮暨計畫)（主持人）。

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19. 探討細胞如何調和兩種不同複雜的生理網絡: 分析Golgi complex在細胞週期S期細胞快速行進時所扮演的角色 (Exploring how cells harmonize two different complicated biochemical networks: the role of Golgi complex in S phase dependent cell migration)，MOST 105-2320-B-260-001-MY3，執行期限：2016/08/01~2019/07/31 (科技部計畫)（主持人）。

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18. 分析p38/NF-kB和JNK1/2在HURP調節Golgi complex生成中的角色 (Exploring the role p38-NF-kB and JNK1-2 in the HURP-regulated Golgi formation)，TCVGH-NCNU1057905，執行期限：2016/01/01~2016/12/31 (榮暨計畫)（主持人）。

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17. 透過分析HURP p725調控Golgi complex結構之重要性與機制，了解Golgi complex形成新月形的原因 (Dissection of the role of HURP p725 in the assembly of Golgi ribbon)，104-2311-B-260 -001 -，執行期限：2015/08/01~2016/07/31 (科技部計畫)（主持人）。

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16. NF-кB在HURP所調控穩定性微管與高基氏體組裝中的角色 (The role of NF-kB in HURP-regulated formation of stable microtubule and Golgi ribbon), TCVGH-NCNU1047906，執行期限：2015/01/01~2015/12/31 (榮暨計畫)（主持人）。

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15. 穩定性微管在HURP調控高基氏體結構之角色 (The role of stable microtubule in HURP-regulated Golgi assembly)，計畫編號：MOST 103-2311-B-260 -001，執行期限：2014/08/01~2015/07/31(科技部計畫)（主持人）。

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14. NF-κB於Aurora-A/HURP所引發細胞轉型中的角色 (The role of NF-Kb B in Aurora-AHURP cascade-induced cell transformation)，計畫編號： TCVGH-NCNU1037902，執行期限：2014/01/01~2014/12/31 (榮暨計畫)（主持人）。

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13. Aurora-A透過磷酸化Astrin調節細胞分裂期之研究 (Regulation of mitosis progression by Aurora-A-dependent Astrin phosphorylation)，計畫編號：TCVGH-NCNU1027903，執行期限：2013/01/01~2013/12/31 (榮暨計畫)（主持人）。

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12. HURP調控Golgi結構與cyclin E1基因表達之機制 (Exploration of the underlined mechanisms by which HURP regulates Golgi formation and cyclin E1 expression)，計畫編號：101-2311-B-260-001，執行期限：2012/08/01~2013/07/31 (國科會計畫)（主持人）。

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11. PRMT5/HURP促進細胞轉型之研究 (The contribution of PRMT5/HURP cascade to cell transformation)，計畫編號：101DCC0100002，執行期限：2012/01/01~2012/12/31 (榮暨計畫)（主持人）。

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10. Aurora-A/HURP 致細胞轉形機轉之研究 (Exploration of the Aurora-A/HURP- dependent oncogenic pathway)，計畫編號：NSC 98-2320-B-260-001-MY3，執行期限：2009/08/01~2012/07/31(國科會計畫)（主持人）。

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9. 去磷酸化對HURP的調控：PP1α、PP1β、PP1γ以及PP2Cβ對於HURP蛋白質行為功能上的調控 (Regulation of HURP by dephosphorylation: the role of PP1α, PP1β, PP1γ and PP2Cβ in the control of protein behavior and function of HURP)，計畫編號：TCVGH-NCNU 1007902，執行期限：2011/01/01~2011/12/31 (榮暨計畫)（主持人）。

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8. 以修飾聚精胺酸固相萃取技術及質譜技術分析HURP磷酸化位置，計畫編號：99B4，執行期限：2009/01/01 ~ 2011/12/31(大學跨學門科學人才培育銜接計畫)（主持人）。

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7. 發展觀測活體組織及單一細胞基因活性之顯微螢光技術，計畫編號：99-2627-M-260-001，執行期限：2010/08/01~2013/10/31 (跨領域研究計畫)（共同主持人）。

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6. 分析HURP與MEP50交互作用之細胞功能 (The cellular function of the interaction of HURP and MEP50)，計畫編號：TCVGH-NCNU987905，執行期限：2009/01/01~2009/12/31(榮暨計畫)（主持人）。

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5. 透過分析SLAN與Aurora-A的交互調控了解SLAN的分子活性 (Exploring the cellular function of SLAN by studying the interplay of SLAN and Aurora-A)，計畫編號：TCVGH-987324D，執行期限：2009/01/01~2009/12/31 (台中榮民總醫院)（主持人）。

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4. Aurora-A調控HURP控制紡槌絲之研究 (The role of Aurora-A-catalyzed HURP phosphorylation in spindle formation)，計畫編號：TCVGH-NCNU 977901，執行期限：2008/01/01~2008/12/31 (榮暨計畫)（主持人）。

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3. HURP細胞功能之分子機制探討 (The systematic exploration of the molecular activities of HURP)，計畫編號：NSC 96-2320-B-260-001，執行期限：2007/08/01~2008/07/31(國科會計畫)（主持人）。

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2. Aurora-A調控HURP進出細胞核及其對於細胞轉型之研究 (The regulation of HURP nuclear targeting and cell transformation by Aurora-A)，計畫編號：TCVGH-NCNU967906，執行期限：2007/01/01~2007/12/31 (榮暨計畫)（主持人）。

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1. Aurora-A 磷酸化與調節Astrin之研究(Phosphorylation and regulation of Astrin by Aurora-A)，計畫編號： NSC 95-2314-B-260-001，執行期限：2006/10/01~2007/07/31(國科會計畫)（主持人）。

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實驗室碩博士論文(Dissertation and Thesis)

朱晨語 2023 Aggresome與Golgi在介導抗癌藥物耐藥性和副作用中的角色(The role of aggresome and Golgi apparatus in the induction of

                      anticancer drugs’ resistance and side effects)

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吳禾廉 2022 PP2Ac與PP1α在細胞移行以及MG132誘導的毒性中所扮演的角色(The Roles of PP2Ac and PP1α in The Regulation of Cell  

                      Migration and MG132-Induced Cell Toxicity)

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鄭巧筠 2021 Poh1、Vimentin p72和HURP p725形成蛋白質複合體，並且調控MG132所誘導的aggresome形成(Poh1, Vimentin p72, and HURP                       p725 form a protein complex and are essential for MG132-induced aggresome formation)

 

黃鈺庭 2021 Poh1、Vimentin p72和HURP p725蛋白質複合體透過調節中心體與吸引HDAC6來促進aggresome產生 (The protein complex

                      containing Poh1, Vimentin p72 and HURP p725 controls aggresome formation via regulating centrosome and attracting

                      HDAC6)

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廖奕豪 2018 aggresome形成時NF-кB的調控與其對aggresome形成的影響 (NF-кB is regulated to control aggresome formation and

                      subsequent autophagosome recruitment)

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萬長鑫 2018 Aurora-A磷酸化SLAN之分子機制與細胞功能分析 (Molecular mechanisms and cellular functions for the Aurora-A-induced

                      SLAN phosphorylation )

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陳若梅 2017 探討致癌蛋白Aurora-A以及其下游受質HURP對於細胞增生以及高基氏體組成之探討 (The mechanisms by which Aurora-A and its

                      downstream substrate HURP regulate cell proliferation and Golgi complex assembly)(博士論文)

 

廖昱婷 2017 分析HURP p725/Vimentin複合體如何調控Golgi complex的形狀與定位 (Unraveling how the HURP p725 /Vimentin complex

                      regulates the shape and positioning of Golgi complex)

 

楊淑婷 2016  新月形的HURP p725藉著吸引與穩定Golgi組裝蛋白將Golgi形塑成新月狀 (The Ribbon-Like Fiber of HURP p725 Shapes Golgi as a

                       Ribbon Form Via Attracting and Stabilizing Golgi Assembly Factors)

 

王怡文 2015 CLNS1A在肺癌細胞株H1299中引發細胞轉型的分子機制探討 (The molecular mechanisms of CLNS1A-induced cell transformation

                       in lung cancer cell line H1299)

 

郭奕群 2015 探討PRMT5甲基化HURP的機轉及其在細胞中的生理意義 (The mechanisms and cellular significances of PRMT5-induced HURP

                      methylation)

 

劉俊志 2014 HURP透過提高穩定性微管穩定度促進高基氏體之組成 (HURP regulates Golgi structure via stabiliznig stable microtubules)

 

陳可心 2010 探討SLAN在肺癌細胞株中扮演的角色 (The role of SLAN in lung cancer cell lines)

 

顧家鳳 2010 由決定SLAN功能性區段和研究SLAN與Aurora-A之相互調控分析SLAN之分子活性 (Exploration of SLAN molecular activities:

                      determination of SLAN funtional domains and analysis of the mutual regulation of SLAN and Aurora-A)

 

魏同佑 2010 甲基轉移酶複合體於細胞轉型的角色 (The role of methylosome in cell transformation)

 

陳若梅 2009 ENO-1對於細胞轉型之角色探討 (The role of ENO1in cell transformation)

 

林欣怡 2009 HURP的進出核調控及其在有絲分裂期的角色 (The regulation of HURP nuclear targeting and its role in miotsis progression)

 

鍾昌明 2008 Aurora-A調控HURP進出細胞核及其對於細胞轉型之研究(The regulation of HURP nuclear targeting and cell transformation by

                      Aurora-A)

 

李殿強 2008 可能抑癌蛋白SLAN對於細胞週期調控之研究 (The role of a potential tumor suppressor protein SLAN in the regulation of cell 

                     cycle progression)

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研討會論文(Conference papers)

 

86. Huang Yu-Ting, , Chang-Tze Ricky Yu. The 3P complex (Poh-1, HURP p725 and Vimentin p72 regulates the functional and structural transformation from centrosome to aggresome. Dec 8-12, 2019; The 20th General Assembly of the Federation of Asian Chemical Societies and the 18th Asian Chemical Congress, Taipei, Taiwan. P33-008.

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85. Yun-Ru Huang, Chang-Tze Ricky Yu. Golgi intrinsic and extrinsic mechanisms guide its repositioning during directional cell migration. Dec 8-12, 2019; The 20th General Assembly of the Federation of Asian Chemical Societies and the 18th Asian Chemical Congress, Taipei, Taiwan. P17-011.

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84. 廖昱婷、李明璟、余長澤。分析HURP p725與Vimentin intermediate filament的相互調控。106年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會海報。

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83. Yi-Hao C Liao, Jo-Mei M Chen, Chiao-Yun C Cheng, Min-Chieh M Ke, Chang-Tze R Yu. The aggresome formation and subsequent autophagosome recruitment depend on modifications of alpha-tubulin. 2018 Apr 9-13; Cold Spring Harbor Asia Conference on Ubiquitin family, autophagy and diseases. Suzhou, China, poster #18.

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82. Jo-Mei M Chen, Yi-Hao C Liao, Chiao-Yun C Cheng, Yu-Ting J Huang, Min-Chieh M Ke, Chang-Tze R Yu. The role and regulation of NF-κB during aggresome-autophagy formation. 2018 Apr 9-13; Cold Spring Harbor Asia Conference on Ubiquitin family, autophagy and diseases. Suzhou, China, poster #12.

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81. Yun-Ru J Huang, Tong-You W Wei, Yi-Chun Kuo, Chang-Tze R Yu. Cdc42 mediates the coupled migration of centrosome and Golgi complex during directional cell migration. 2018 Apr 9-13; Cold Spring Harbor Asia Conference on Ubiquitin family, autophagy and diseases. Suzhou, China, poster #15.

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80. 萬長鑫1, 廖昱婷1, 連喬萱 1, 魏同佑1,夏君毅2,陳焜結3,余長澤*1 Aurora-A-catalyzed phosphorylation of SLAN regulates cytokinesis. 2018 Mar; The 33th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #64 (指導學生獲大會優秀論文).

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79. Yu-Ting Amber Liao, Shu-Ting Yang, Jo-Men Maureen Chen, Shao-Chih Chiu, Jiun-Yi Hsia and Chang-Tze Ricky Yu. The interplay of HURP and Vimentin contributes to the positioning of Golgi complex. 7th Annual Word Congress of Molecular and Cell Biology, Xi’an, China (2017).

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78. Yun-Ru Jaoying Huang, Tong-You Wade Wei, Yi-Chun Kuo, Jo-Men Maureen Chen, Yu-Ting Amber Liao, Chun-Chih Jared Liu and Chang-Tze Ricky Yu. PRMT5-induced HURP methylation regulates the protein stability, Golgi stabilizing and cell migration stimulatory activities of HURP. 7th Annual Word Congress of Molecular and Cell Biology, Xi’an, China (oral report) (2017).

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77. Jo-Men Maureen Chen, Shao-Chih Chiu, Shu-Ting Yang, Tong-You Wade Wei, Yu-Ting Amber Liao, Chun-Chih Jared Liu, Yun-Ru Jaoying Huang, Jiun-Yi Hsia and Chang-Tze Ricky Yu. The contribution of perinuclear cytoskeletons to the formation and positioning of Golgi ribbon. 7th Annual Word Congress of Molecular and Cell Biology, Xi’an, China (oral report) (2017).

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76. Jo-Mei Maureen Chen, Shao-Chih Chiub, Shu-Ting Yang, Tong-You Wade Wei, Chun-Chih Jared Liu, Jiao-Ying Huang, Jiun-Yi Hsia, Chang-Tze Ricky Yu. NFkB在HURP所調控穩定性微管與高基氏體組裝中的角色。104年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會，P84，海報(競賽第一名)。

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75. Ru-Yi Nina Chen, Jiun-Yi Hisa, Ya-Hui Candice Wang, Mei-Hsuan Ho, Chang-Tze Ricky Yu. PP1α differentially regulates cell proliferation in different cell types. 2016 Mar; The 31th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #402 (指導學生獲大會優秀論文).

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74. Yun-Ru Huang, Tung-You Wade Wei, Jo-Mei Maureen Chen, Yi-Chun Kuo, Chun-Chih Liu, Jiun-Yi Hisa, Chang-Tze Ricky Yu. The PRMT5-catalyzed methylation and JMJD6-indcued demethylation of HURP regulates Golgi flexibility and directional cell migration. 2016 Mar; The 31th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #379.

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73. Shu-Ting Yang, Chun-Chih Liu, Ru-Yi Nina Chen, Yun-Ru Huang, Jo-Mei Maureen Chen, Tung-You Wade Wei, Chang-Tze Ricky Yu. The ribbon-like fiber of HURP p725 shapes Golgi as a ribbon form via attracting and stabilizing Golgi assembly factors。2016 Mar; The 31th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #388 (指導學生獲大會優秀論文).

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72. 陳若梅，余長澤，謝允廷，曾振志. Aurora-A透過Astrin與HURP/NF-kB調控M與G1/S期的行進. 104年度中區各大學院校暨台中榮民總醫院合作研究計畫聯合成果發表會，台中，p86，海報(競賽第一名)。

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71. 余長澤，Aurora-A透過Astrin與HURP/NF-kB調控M與G1/S期的行進. 104年度中區各大學院校暨台中榮民總醫院合作研究計畫聯合成果發表會，台中，p79-80，海報(口頭報告競賽第二名)。

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70. Chang-Tze Ricky Yu*, Jiao-Ying Huang, Tong-You Wade Wei, Yi-Chun Kuo and Jo-Mei Maureen Chen. The PRMT5-induced methylation of HURP retards directional cell migration via impairing polarized assembly of the Golgi complex. 2015 Cell and Molecular Biology Conference, Nanjing, China, #449.

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69. Jo-Mei Maureen Chen*, Shao-Chih Chiu, Shu-Ting Yang, Tong-You Wade Wei, Chun-Chih Jared Liu, Jiao-Ying Huang, Jiun-Yi Hsia, Chang-Tze Ricky Yu. NF-kB Is Crucial For HURP-Dedicated Assembly of Golgi Ribbon Formation. 2015 Cell and Molecular Biology Conference, Nanjing, China (oral presentation).

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68. Yi-Wun Wang (王怡文), Shao-Chih Chiu (邱紹智) , Jiun-Yi Hsia (夏君毅), Jo-Mei Maureen Chen (陳若梅), Tung-You Wade Wei (魏同佑), Hui-Yu Cho (卓蕙瑜), Chang-Tze Ricky Yu (余長澤). CLNS1A promotes cell transformation through its chloride channel- and PRMT5-regulating activities. 2015 Jan; Twenty Third Symposium on Recent Advances in Cellular and Molecular Biology. Kengting, R.O.C. Abs. #7, page 67.

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67. 陳若梅, 魏同佑, 夏君毅, 余長澤. Aurora-A透過磷酸化Astrin調節細胞分裂期之研究. 103年度中區各大學院校暨台中榮民總醫院合作研究計畫聯合成果發表會，台中，p79-80，海報(競賽第一名)。

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66. 劉俊志Chun-Chih Liu, 郭奕群Yi-Chun Kuo, 楊淑婷Shu-Ting Yang, 黃椒楹Jiao- Ying Huang, 陳若梅Jo-Mei Maureen Chen,魏同佑Tung-You Wade Wei, 余長澤Chang-Tze Ricky Yu*. HURP的甲基化調控染色體的排列及高基氏體的結構: 小小官能基對於巨型生命分子的決定性影響， 2013中國化學年會，埔里，#BM055, page B138，海報(生物醫學組壁報論文優秀獎)。

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65. Yi-Chun Kuo, Jiao- Ying Huang, Chun-Chih Liu, Shu-Ting Yang, Tung-You Wade Wei, Chang-Tze Ricky Yu*. The contribution of PRMT5/HURP cascade to cell transformation. 101年度中區各大學院校暨台中榮民總醫院合作研究計畫聯合成果發表會，台中，p79-80，海報(競賽第一名)。

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64. Jo-Mei Maureen Chen, Shao-Chih Chiu, Shin-Yi Lin, Cheong-Meng Chong, Jiun-Yi Hsia, Tong-You Wade Wei, Chia-Feng Ku, Yin Roy Lo, Jenn-Jhy Tseng, Kuo-Lin Liu, Chang-Tze Ricky Yu*. Aurora-A-induced phosphorylation of HURP targets HURP into nucleus, accelerates G1/S progression and regulates cyclin E1 expression. 2013 Mar; International Conference on Life Science & Biological Engineering. Tokyo, Japan. Abs. #495, p150.

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63. Yi-Wun Wang, Po-Hsin Eric Yao, Jou-May Maureen Chen, Tung-You Wade Wei, Hui-Yu Cho, Shao-Chih Chiu, Jiun-Yi Hsia, Chang-Tze Ricky Yu*. CLNS1A is upregulated in lung cancer tissues and stimulates cell proliferation and migration. 2013 Jan; Twenty First Symposium on Recent Advances in Cellular and Molecular Biology. Kengting, R.O.C. Abs. #11, page 75.

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62. Chiao-Hsuan Lian, Jou-May Maureen Chen, Chun-Chih Lin, Tong-You Wade Wei, Cheng-Yu Tsai, Jiun-Yi Hsia, Chang-Tze Ricky Yu*. Aurora-A regulates several activities of SLAN through phosphorylation of SLAN at T573. 2013 Jan; Twenty First Symposium on Recent Advances in Cellular and Molecular Biology. Kengting, R.O.C. Abs. #137, page 210.

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61. Chun-Chih Liu, Yi-Chun Kuo, Shu-Ting Yang, Jiao- Ying Huang, Jou-May Maureen Chen, Po-Hsin Eric Yao, Tung-You Wade Wei, Chang-Tze Ricky Yu*. PRMT5-induced methylation of HURP regulates mitosis progression and Golgi structure and stability. 2013 Jan; Twenty First Symposium on Recent Advances in Cellular and Molecular Biology. Kengting, R.O.C. Abs. #215, page 292.

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60. Chang-Tze Ricky Yu*. Aurora-A regulates spindle configuration through phosphorylation of Astrin and HURP. 2013 Jan; 第三屆毒理學聯合研討會, 中山醫學大學, 台中, 口頭報告。

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59. Chag-Tze Ricky Yu*. The novel protein SLAN downregulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A. 2012 Aug; 清大生科院毒理學研討會, 新竹, 台灣, 口頭報告。

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58. 何梅萱，劉俊志，羅尹，林珍儀，曾振志，余長澤*。去磷酸化對HURP的調控：PP1α、PP1β、PP1γ和PP2Cβ對於HURP蛋白質行為功能上的調控。2012，Jun; 100年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會，台中，p47-48，口頭報告(競賽第二名)與海報(競賽第一名)。

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57. Chag-Tze Ricky Yu*. PRMT5 is a potential oncoprotein upregulating G1 phase cyclins/CDKs and PI3K/AKT cascade. 2012 Feb; 毒理學研討會, 高雄醫學大學, Oral report.

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56. Chiao-Hsuang Lian, Yi-Wun Wang, Chun_chih Lin, Jou-May Maureen Chen, Jiun-Yi Hsia, Chang-Tze Ricky Yu*. SLAN regulates nuclear targeting of Jab1. 2012 Feb; Twentieth Symposium on Recent Advances in Cellular and Molecular Biology. Kaohsiung, R.O.C. Abs. #128, page 185.

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55. Yi-Chun Kuo, Tung-You Wei, Jou-May Maureen Chen, Jiun-Yi Hsia, Chang-Tze Ricky Yu*. The cellular significance of PRMT5-induced HURP methylation. 2012 Feb; Twentieth Symposium on Recent Advances in Cellular and Molecular Biology. Kaohsiung, R.O.C. Abs. #133, page 190.

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54. Chang-Tze Ricky Yu*. Aurora-A regulates several aspects of HURP through phosphorylating different serine residues. 2011 Sep; 跨學門科學人才培育交流研討會, 中央大學, 中壢 (Oral presentation)。

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53. Jo-Mei Maureen Chen, Y.C. Hseih, Jiun-Yi Hsia, Shih-Lan Hsu, Chang-Tze Ricky Yu*, Shao-Chih Chiu. ENO-1 selectively stimulates cell proliferation in lung cancer. 2011 Apr; The 4th Pan Pacific Symposium on Stem Cells and Cancer Researches. Taichung, Taiwan. PG-03.

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52. Yin-Roy Lo , Mei-Hsuan Ho, Chen-Yi Lin, Jou-May Chen, Hui-Yu Cho, Chih-Che Wu, Chang-Tze Yu*. Phosphorylation and dephosphorylation control of HURP. 2011 Apr; The 4th Pan Pacific Symposium on Stem Cells and Cancer Researches. Taichung, Taiwan. PG-05.

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51. Mei-Hsuan Ho, Jou-May Maureen Chen, Chang-Tze Yu*. HURP 43-244 stimulates cell proliferation by increasing cylin E1 expression. 2011 Mar; The 26th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #18.

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50. Mei-Hsuan Ho, Yin-Roy Lo, Yi-Chun Kuo, Chang-Tze Ricky Yu*. Dephosphorylation control of HURP. 2011 Feb; Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kaohsiung, R.O.C. Abs. #32, page 94.

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49. Yin-Roy Lo, Chen-Yi Lin, Yi-Chun Kuo, Chang-Tze Ricky Yu*. Aurora-A regulates various activities of HURP through phosphorylating HURP at different serine residues. 2011 Feb; Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kaohsiung, R.O.C. Abs. #345, page 417.

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48. Ztu-yi Yolanda Chen, Ke-Shin Chen, Chia-Feng Gu, Chang-Tze Ricky Yu*. SLAN regulates mitosis progression. 2011 Feb; Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kaohsiung, R.O.C. Abs. #217, page 286.

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47. Chang-Tze Ricky Yu, Jiun-Yi Hsia, Yun-Chih Hseih, Li-Jen Su, TC Lee, Ke-Shin Chen, Chia-Feng Ku, Jou-May Maureen Chen, YCG Lee, Chi-Ying F. Huang, Yu-Chung Wu, Tong-You Wade Wei, Shih-Lan Hsu*. The novel protein SLAN downregulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A. 2010 Sep; Cold Spring Harbor Asia Conference on Computational Biology. Suzhou, China, p39.

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46. Jou-May Maureen Chen, Jiun-Yi Hsia, Tsai-Feng Fu, Tai-Shan Cheng, Yi-Ren Hong, Tong-You Wade Wei, Gia-Feng Gu, Chan-Han Chen, Mau-Sun Chang, Chang-Tze Ricky Yu*. Identification of Astrin as a substrate of Aurora-A. 2010 Sep; Cold Spring Harbor Asia Conference on Computational Biology. Suzhou, China, p14.

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45. 魏同佑、林欣宜、曾振志、余長澤*。分析HURP與MEP50交互作用之細胞功能，2010 May; 台中榮民總醫院九十八年度與中區各大院校合作研究計畫聯合成果發表會，台中，p151，口頭報告。

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44. 魏同佑，余長澤*。The potential oncoprotein complex methylates another potential oncoprotein HURP。2010 Mar; The 25th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #253.

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43. 魏同佑，林欣宜，林伯儒，曾振志，余長澤*。HURP contains several important cis elements regulating mitotic events. 2010 Mar; The 25th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #723.

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42. 陳若梅，黃奇英，余長澤*。The mechanisms by which Aurora-A employ to stabilize HURP. 2010 Mar; The 25th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #725.

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41. 陳可心，顧家鳳，李殿強，夏君毅，徐士蘭，余長澤*。The spindle or spindle matrix associated novel protein SLAN negatively regulates mitosis progression by arresting cells in mitosis, blocking cytokinesis and inactivating Aurora-A. 2010 Mar; The 25th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #736.

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40. 陳銘洲，滕傑林，徐士蘭*，余長澤*。The molecular mechanisms of Sunitinib-induced cell death in human acute myeloid leukemia cells. 2010 Mar; The 25th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #14.

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39. Shin-Yi Lin, Tong-You Wade Wei, Po-Ru Lin and Chang-Tze Ricky Yu*. Systematic search for the HURP function motifs regulating spindle targeting of HURP, several aspects of spindle behavior, and mitotic progression. 2010 Jan; Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #74.

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38. Ke-Shin Chen#, Chia-Feng Gu#, TC Lee, Jiun-Yi Hsia, Shih-Lan Hsu and Chang-Tze Ricky Yu*. A novel protein SLAN with multiple subcellular localizations is able to regulate mitosis progression. 2010 Jan; Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #147.

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37. Jou-May Maureen Chen, YC Hseih, Jiun-Yi Hsia, Chang-Tze Ricky Yu* and Shih-Lan- Hsu*. 2010 Jan; ENO1 is selectively upregulated in lung cancer tissues and specifically transforms lung caner cell line H460/H1299. Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #170.

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36. Tong-You Wade Wei and Chang-Tze Ricky Yu*. Identification of the methylosome components PRMT5, CLNS1A and MEP50 as potential oncogenes. 2010 Jan; Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #271.

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35. Jou-May Maureen Chen, Pei-Hua Chen, Tai-Shan Cheng, Yi-Ren Hong, Chi-Ying F. Huang, Gia-Feng Gu and Chnag-Tze Ricky Yu*. Aurora-A-dependent Astrin phosphorylation modulates mitosis progression. 2010 Jan; Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #279.

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34. Wan-Chin Ma, Shin-Yi Lin and Chang-Tze Ricky Yu*. The mechanisms by which Aurora-A regulates nuclear targeting of HURP. 2010 Jan; Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #116.

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33. Shin-Yi Lin, Cheong-Meng Chong, Tong-You Wade Wei, Jenn-Jhy Tseng, Chang-Tze Ricky Yu*. Dissection of HURP cis-elements regulating spindle localization & regulation, and cell cycle progression. 2009, May; 九十七年度中區十大院校暨台中榮民總醫院合作研究計畫聯合成果發表會, 台中, 口頭報告.

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32. Chien-Shun He, Shih-Lan Hsu *, Chang-Tze Ricky Yu*. High Insulin Decreases Adiponectin Expression But Increases Leptin and Fatty Acid Production in Differentiated 3T3-L1 Adipocytes. 2009 Mar; The 24th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #346.

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31. Shin-Yi Lin, Tong-You Wade Wei, Chang-Tze Ricky Yu*. The Regulation of HURP Spindle Targeting and Its Role In Mitosis Progression. 2009 Mar; The 24th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #766.

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30. Ke-Shin Chen, TC Lee, Jiun-Yi Hsia, Shih-Lan Hsu, Chang-Tze Ricky Yu*. The Role of SLAN in Cell Proliferation in Lung Cancer Cell Lines. 2009 Mar; The 24th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #781.

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29. Tong-You Wade Wei, Shin-Yi Lin, Chang-Tze Ricky Yu*. The Cellular Significance of HURP Methylation. 2009 Mar; The 24th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #799.

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28. Gia-Feng Gu, TC Lee, Jiun-Yi Hsia, Shih-Lan Hsu#, Chang-Tze Ricky Yu*. Dissection of the Molecular Activities of SLAN: The Interplay Between SLAN and Aurora-A. 2009 Mar; The 24th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #800.

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27. Tong-You Wade Wei, Shin-Yi Lin, Chang-Tze R. Yu*. Characterization and cellular significance of the interaction of HURP and methylosome. 2009 Feb; Seventeenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #333.

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26. Cheong-Meng Chong, Shin-Yi Lin, Wan-Chin Ma, Chang-Tze R. Yu*. The regulation of HURP nuclear targeting and cell transformation by Aurora-A. 2009 Feb; Seventeenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #334.

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25. TC Lee, YC Hseih, YW Chen, JY Hsia, Chang-Tze R. Yu*, SL Hsu*. SLAN, an anti-cell proliferation protein, is able to regulate spindle and interact with a spindle regulator, Aurora-A. 2008 Mar; The 23th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #800.

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24. CM Chong, CY Huang, JJ Tseng, Chang-Tze R. Yu*. The regulation of HURP nuclear targeting and spindle formation by Aurora-A. 2008 Mar; The 23th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #801.

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23. SY Lin, Chang-Tze R. Yu*. Identification of the role of HURP interaction protein, MEP50, in cell transformation and spindle formation. 2008 Mar; The 23th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #802.

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22. JM Chen, YC Hseih, YJ You, JY Hsia, Chang-Tze R. Yu*. The role of Enolase1 in cell transformation. 2008 Mar; The 23th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #803.

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21. PH Chen, Y Chen, TS Cheng, YL, Hsiao, YR Hong, CY Huang, Chang-Tze R. Yu*. Exploring the cellular significance of Aurora-A-dependent phosphorylation of Astrin. 2008 Mar; The 23th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #809.

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20. YC Hseih, TC Lee, YW Chen, JY Chen, Chang-Tze R. Yu*, SL Hsu*. Identification of spindle regulator protein, SLAN, as a potential tumor suppressor. 2007 Nov; The 1th International Cancer Symposium in CMU&H, Taichung, Taiwan. Abs. #2-4.

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19. YC Hseih, TC Lee, YW Chen, JY Chen, Chang-Tze R. Yu*, SL Hsu*. Identification of spindle regulator protein, KIAA0256 as a potential tumor suppressor. The 22th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #337 (2007).

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18. YC Hseih, Chang-Tze R. Yu, YZ You, JY Hsia, TC Lee, SL, Hsu*. Exploration of the role of Enolase-1 in cell transformation. Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #280 (2007).

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17. TS Cheng, YL Hsiao, CC Lin, CM Hsu, MS Chang, CI Lee, Chang-Tze R Yu, CYF Huang, SL Howng, YR Hong. The interplay of cglycogen synthase 3beta and Astrin in spindle microtubule assembly. Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #201 (2007).

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16. YC Hseih, Chang-Tze R. Yu, YZ You, YZ Chen, ZH Tsai, LM Chen, SL Hsu*. Establishment of assay platforms exploring the genes involved in lung cancer development. The 21th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #331 (2006).

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15. Chang-Tze R. Yu, Yun-Ling Hsiao, Tai-Shan, Cheng, Yi-Ren, Hong, Jiunn-Chyi Wu, Chan-Han Chen, Mau-Sun Chang, Shih-Lan Hsu, and Chi-Ying F. Huang*. Identification of Astrin as a substrate of Aurora-A. Fourteenth Symposium on Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #66 (2006).

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14. Chien-Chih Chen, Jia-Rung Tsia, Chang-Tze R. Yu, Gee-Chen Chang, Shih-Lan Hsu*. p53 mediates ZD1839-induced apoptosis in A549 cells. Fourteenth Symposium on Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #64 (2006).

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13. Tai-Shan Cheng, Yun-Ling Hsiao, Mau-Sun Chang, Chu-I Lee, Chang-Tze R. Yu, Chi-Ying F. Huang, Yi-Ren Hong*. Human Ninein is required for targeting Astrin to centrosome. Fourteenth Symposium on Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #173 (2006).

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12. Chang-Tze R. Yu, Chen-Kung Chou, Fen-Hwa, Wong, Chiying F. Huang*. Regulation of HURP nucleus targeting by Aurora-A. The Twelfth Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. Abs. #680 (2005).

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11. Chang-Tze R. Yu, Chi-Ying F. Huang*, Fen-Hwa Wong. Aurora-A phosphorylates c-Fos and regulates its protein complex formation. Thirteenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #195 (2005).

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10. Chang-Tze R. Yu, Yong-Shiang Lin, Li-Jen Su, Fen-Hwa Wong, Hsu-Hua Yeh, Su-Liang Chen, Wey-Jinq Lin, Chiun-Jye Yuan, Chi-Ying F. Huang*. Gene expression profiles of Aurora family kinases. Twelfth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #A156 (2004).

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9. Change-Tze R. Yu, Chen-Keng Chou, Chiying F. Huang*. Aurora-A regulates the protein stabilities of its downstream substrates. The third fall camp: Era of functional genomics from biomics, virus infection to protein structure and function. National Cheng Kung University, Tainan, Taiwan, R.O.C. Abs. #P2 (2003).

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8. Jiunn-Chyi Wu, Chang-Tze R. Yu, Tzong-Yueh Chen, Chi-Ying F. Huang*. Identification and characterization of the downstream target of Aurora-A. 16th FAOBMB Symposium, Academia Sinica, Taipei, R.O.C. Abs. #P102 (2002).

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7. Jiunn-Chyi Wu, Feng-Di Tiffang Lung, Tzong-Yueh Chen, Chang-Tze R. Yu, Yuang-Chii G. Lee, Jung-Mao Shu, Cheng-Kung Chou and Chi-Ying F. Huang*. Characterization of Ral-GDS and Ral-A as downstream targets of Aurora-A. The 4th Asian-Pacific Organization for Cell Biology Congress Cell Biology in the post-Genomic Era. Academia Sinica, Taipei R.O.C. Abs. #10-4 (2002).

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6. Chang-Tze R. Yu, Yuan-Chii G. Lee, Li-Jen Su, Jung-Mao Hsu, Hau-Chen Lin, Shu-Chih Chen, Su-Liang Chen, Fen-Hwa Wong, Yi-Ren Hong, Wey-Jinq Lin, Bo-Rue Chen, Chen-Kung Chou, Chi-Ying F. Huang*. Identification of HURP as a substrate of Aurora-A. The 4th Asian-Pacific Organization for Cell Biology Congress Cell Biology in the Post-Genomic Era. Academia Sinica, Taipei R.O.C. Abs. #5-5 (2002).

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5. An-Chi Tian, Yuan-Chii G. Li, Sheng-Yi Lin, Chang-Tze R. Yu, Chi-Ying Huang*. In silico apocalypse: from protein-protein interaction database to kinase substrates Revelation-a case study of Aurora-A/Ipl1p family. Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #A09 (2001).

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4. Tuan-Chii G. Lee, Jung-Mao Hsu, Chang-Tze R. Yu, Jiunn-Chyi Wu, Shiuh-Hwa Yeh, Sheng-Yi, Lin, An-Chi Tien, Cheng-Kung Chou, Chi-Ying F. Huang*. From bioinformatics prediction to function revelation: a role of HURP in ubiquitin-Ligase enzyme (E3), APC and SCF. Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #A185 (2001).

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3. J. C. Wu, T. Y. Chen, Chang-Tze R. Yu, L. J. Su, C. C. Lin, Chiying Huang*. Characterization of the relationship between Aurora-A and its potential substrate-RAL-GDS. Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #A14 (2001).   

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2. Chang-Tze R. Yu, T. Y. Chen, C. K. Chou, Chiying F. Huang*. Identification of the substrates of Aurora-A: implication of Aurora-A mediated oncogenesis. Tenth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #A12 (2001).

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1. Tzong-Yueh Chen, Chang-Tze R. Yu, J-C Wu, Y-M Wu, C-Y F Huang*. Search for downstream targets of human AIK (Aurora/Ip11-related Kinase). Eighth Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, R.O.C. Abs. #S2 (2000).

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